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On the contrary, the activation of mitochondrial STAT-3 inhibited mPTP and thus contributed to cardiac protection [52, 53]

Thus, a diverse set of targets with potentially large differences in hit rates was chosen to test the DOSEDO library, under conditions that would be relevant to a wide range of research capabilities

In aged mice treated for 8 weeks at 10 mg/kg daily, sedentary mice showed approximately 40% greater grip strength than controls, and when combined with exercise, grip strength improved by approximately 60%