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Acetazolamide is the first-line of prophylaxis, FDA approved drug for AMS that works at the level of kidneys and causes bicarbonate diuresis and metabolic acidosis, promoting ventilatory acclimatization to hypoxia 25

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Infected macrophages vary in polarization (M1/M2), metabolism (glycolysis/fatty acid oxidation), and lineage (alveolar macrophages [AMs]/interstitial macrophages [IMs]), all of which influence treatment outcome

Damage to mitochondrial DNA results in loss of mitochondrial membrane potential, impairment in the electron transport chain, and drives the immune and inflammatory responses (Liu and Chen, 2017), (Figure 3)

While both are amphetamines, Dexedrines pure dextroamphetamine composition makes it more targeted, whereas Adderalls combination offers a broader spectrum of effects