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In their healthy state, astrocytes remain indispensable for neuronal support, but their metabolic roles in both health and disease continue to be an active area of research with significant therapeutic potential

Although other branch activations are also involved in RA, such as the cGAS-PI3K-Akt signaling pathway, this review will primarily focus on the cGAS-STING signaling pathway in the following sections (40, 41)

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The direct delivery system ensures the body receives the total dose without loss

Studies involving melatonin and resveratrol were excluded due to high heterogeneity in their populations and because they were not specifically focused on DOR/POR patients (Figure 7)