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5B, lane 47)

AD is a complex, progressive neurodegenerative disorder characterized by cognitive decline, amyloid-beta (A) plaques, and tau protein neurofibrillary tangles

Evaluation of negative geotaxis assay The locomotor performance (negative geotaxis) of PD flies was evaluated as previously described 36

This is clear from both the limited reductions in prevalence achieved over the past decade, and also from the health economic modelling predictions we summarise here