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The reprogramming factors initiate changes in gene expression patterns, leading to the reactivation of pluripotency-associated genes and the suppression of somatic cell-specific genes

Clinical studies show that 50%60% of patients with painful DPN require long-term use of analgesics, and approximately 35% of patients reduce their working hours or even lose their ability to work due to pain (Sadosky et al., 2005

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