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Considering for the induced antiapoptotic proteins after PPI treatment, the cytotoxicity of PPI significantly increased when combined with Bcl-2 inhibitors

elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype

In addition, iron-binding agents such as deferiprone (DFP), DFO, and deferasirox (DFX) prevent the Fenton reaction by binding to surplus iron ions, and research has indicated that these agents serve as safeguards against retinal degeneration in various experimental setups (230, 231)