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In a zebrafish model, compared with C3-carnitine, C18-carnitine and C18:1-carnitine can induce the inhibition of OXPHOS, interfere with the energy supply of cardiomyocytes, and lead to a significant impairment of cardiac systolic function, which manifests as a decreased heart rate and reduced shortening of the atrial and ventricular fractions [21]

21 Central disinhibition Central disinhibition refers to an imbalance between the excitatory and inhibitory side of the nervous system, such that there is reduced inhibition to the spinal cord dorsal horn

(b) increased intracellular concentration of GSH in liver and other tissues

Some women might only find out they have PCD after their newborns are found to have low carnitine levels during newborn screening