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Based on the distribution, a two-tailed Students t-test, paired Students t-test, Mann-Whitney test, or Wilcoxon test were employed to compare the groups

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For decades, research has centered on glucose and lipid metabolism disorders (e.g., insulin resistance and hyperlipidemia) as central drivers of metabolic diseases ( As an essential AAA, phenylalanine (Phe) metabolism is predominantly governed by hepatic phenylalanine hydroxylase (PAH) ( Interestingly, gut microbiota-derived Phe metabolites, such as phenylacetylglutamine (PAGln) and exercise-induced N-lactoyl-phenylalanine (Lac-Phe), demonstrate diverse and beneficial bioactivities in cardiovascular risk modulation and appetite regulation, respectively ( Therefore, understanding the mechanisms by which dysregulated Phe triggers metabolic dysfunction is crucial

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As numerous studies demonstrated the ineffectiveness of L-arginine supplementation on increasing NO synthesis, researchers have begun to explore the potential therapeutic benefits of L-citrulline