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Asteria C, Oliveira JH, Abucham J, Beck-Peccoz P (2000)

The dosing schedule is equivalent to three times per week for nine weeks, less than the recommended dose of three times per week for 16 weeks for skin carcinomas (41)

The cultural shift toward recognizing and treating perimenopausedriven by patient advocacy, social media, and high-profile coveragemeans women are presenting earlier, often in their late 30s and early 40s, with irregular cycles, vasomotor symptoms, sleep disruption, and mood changes

Secondary efficacy outcomes included periodontal probing depth (PD), gingival recession (GR), tooth mobility (TM), bleeding on probing (BOP), and bone defect depth (BDD) at 6 months post-treatment

As explained in the example in the CY 2025 PFS proposed rule (89 FR 61976), if CMS grants a severe supply chain disruption rebate reduction request for a generic Part D rebatable drug or biosimilar that was submitted on November 15, 2024, and that generic Part D rebatable drug or biosimilar is currently in shortage from September 15, 2025, until May 15, 2026, CMS would apply a 75 percent reduction in the total rebate amount for the duration of the applicable period for which the severe supply chain disruption rebate reduction request was granted (that is, October 1, 2024, to September 30, 2025), and then would apply the shortage reduction as proposed in 428.301, beginning with a reduction of 25 percent for a biosimilar or 75 percent for a generic Part D rebatable drug or plasma-derived product that is a biosimilar for the applicable period beginning October 1, 2025