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To understand why timing is such a frequent topic of debate, we first have to look at what glutathione actually does

The primary biological function of glutathione is to act as a non-enzymatic reducing agent to help keep cysteine thiol side chains in a reduced state on the surface of proteins

Another aspect of the present invention embraces a method of screening for a compound that is capable of modulating the biological activity of a HGPRBMY14 polypeptide, comprising providing a host cell containing an expression vector harboring a nucleic acid sequence encoding a HGPRBMY14 polypeptide, or a functional peptide or portion thereof (e.g., SEQ ID NOS:2)

These decisions will play a critical role in determining whether peptide therapies move closer to mainstream clinical use or remain in a more limited regulatory position

This can be from direct alkylation of cysteine residues in the bladder by the glutathione adduct or acrolein that is reformed in the bladder