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KPV-related bulk drug substances briefing document

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As a thiol-disulfide reductase, Trx can catalyse the reduction of disulfides (SS) within oxidized cellular proteins such as peroxiredoxin (Prx, HGNC root symbol PRDX) due to the presence of two cysteines in Trxs active centre, Cys-Gly-Pro-Cys [28]

Recently, the electrochemical approach, utilizing the solid-state electrochemistry of cuprous chloride (CuCl), was developed for the detection and quantification of glutathione [79]