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Description

TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3

& Moellering, R

Ngwu Nwachukwu in the Department of Biochemistry, School of Biological Sciences, Federal University of Technology, Owerri, Imo State, Nigeria

Collectively, these findings suggest that GYY4137 functions as an NF-kB signaling modulator and that treatment with GYY4137 can mitigate macrophage oxidative stress and pyroptosis by inhibiting NF-kB signaling