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However, the effects of alcohol consumption on four cancer mortality subtypes were greater in models that did not control for health expenditure, meaning that health expenditure may confound the association of interest and that its inclusion in the model helps isolate the specific contribution of alcohol consumption to cancer mortality trends

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As between-study heterogeneity can be underestimated or even zero when the number of studies is small 196,197 , we used Fishers information matrix to estimate the uncertainty of the heterogeneity 198 and incorporated that uncertainty into the final results