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It is now recognized that the pathological process of AILI includes multiple intra- and extracellular activities, such as mitochondrial oxidative stress, endoplasmic reticulum stress, aseptic inflammation, bile acid cycle, and microcirculatory dysfunction ( in vitro predictive models, and prevention and treatment of AILI

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It was reported that Klotho restrained IGF signalling, which protected against renal hypertrophy in diabetic mice or cystic expansion in mice with polycystic kidney disease 33,34

Human trials are needed

Microbiota modulate sympathetic neurons via a gut-brain circuit