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The primary endogenous enzymatic source of O 2 and H 2 O 2 are through the electron transport chain (ETC) in mitochondria and transmembrane NADPH oxidases (NOXs) ( Figure 1 In SLE, ROS play an important role in cellular signaling and are considered hazardous reactive particles to the cells because they damage the intracellular proteins, lipids, and nucleic acids, producing toxic base pairs, leading to DNA damage

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