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The brain, despite representing only about 2% of body weight, consumes approximately 20% of the body's oxygen, generating substantial oxidative stress as a byproduct of its high metabolic activity

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Eye Vision 4:17 Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang L-L (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan