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Eccentrocytes and cells containing Heinz bodies have less deformability and more rigidity, making them more likely to be lysed or removed from circulation by the spleen

Since aging is a primary risk factor in neurodegenerative diseases, it is likely that the age-dependent reduction in microbial species diversity, including alterations in relative abundances of region-specific microbes, further facilitates persistent degradation and damage of gut mucosal and gut epithelial layers and increases infiltrations of bacterial toxins (Qin et al., 2007

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doi: 10.1172/JCI135536 94 BerthierCCZhangHSchinMHengerANelsonRGYeeBet al

Lett Appl Microbiol 43:211214 Lin J, Liao XY, Du GC, Chen J (2009) Enhancement of glutathione production in a coupled system of adenosine deaminase-deficient recombinant Escherichia coli and Saccharomyces cerevisiae