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2 Organ-on-chip in the 3D in vitro models framework OoCs allow researchers to model human diseases in the lab using immortalized or donor-derived cells cultured in organ-specific microenvironments

Hyperglycemia induces endoplasmic reticulum stress in atrial cardiomyocytes, and mitofusin-2 downregulation prevents mitochondrial dysfunction and subsequent cell death

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As far as medical issues go, I dont think there is a single surgery on the planet that has the potential for such a huge improvement in quality of life with such little hassle or discomfort for the patient