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AMPK, a modulator of autophagy, elicits its actions through the activation of SIRT-1 to enhance autophagy and halt apoptosis (Meijer and Codogno 2007)

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Gaede L, Liebetrau C, Blumenstein J, Troidl C, Drr O, Kim WK, et al

We next attempted to rescue mitochondrial oxidative phosphorylation and glycolysis by co-supplementation with antioxidants, both cell-wide (2.5 mM GSH and 25 M Trolox) and mitochondrial-targeted [10 nM mitoquinol (MQ) and 1 nM SKQ1] (22, 23)

In vivo treatment with SFN resulted in higher NRF2 and p-NRF2 expression in SFN-treated mice compared to IMQ-induced psoriatic mice (Fig

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