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When the extent of such injury overwhelms DNA repair capacity mechanisms, the subsequent alterations in mitochondrial biology stimulate the activation of the genes responsible for stressresponse, hereby inducing apoptosis [116]

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Secondly, NPT ensemble equilibration (constant particle number, pressure, and temperature) followed with a 100 ps simulation at 1 bar, aiming to enable the system to adapt to the specified pressure, thereby stabilizing the density of the system