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The third clinically used CDK4/6 inhibitor is ribociclib, which also shows potential pro-senescence effects [88]

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The power of fluorescence spectroscopy in application to proteins is reflected in the ability of this technique to provide characterization of protein flexibility across a wide range of timescales, from picoseconds to seconds and even minutes, with the specific timescale observed being dependent on the type of motion being measured and the fluorescence method used