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Commonly Reported (Intranasal): Mild stinging or irritation in nasal passages (transient, resolves within minutes) Nasal dryness with repeated daily use Mild taste or odor disturbance immediately after administration Uncommonly Reported: Headache (mild, typically with higher doses) Dizziness (transient) Fatigue (paradoxical, reported rarely) Notably Absent: Sedation or drowsiness (consistently absent across clinical comparisons) Cognitive impairment or psychomotor slowing Tolerance development within standard 14-day courses Physical dependence or withdrawal symptoms upon cessation Rebound anxiety after treatment discontinuation Muscle relaxation or ataxia Serious Adverse Events: No serious adverse events have been attributed to Selank in published clinical literature

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(2003) showed that KPV suppressed inflammatory cytokine production even in the presence of melanocortin receptor antagonists, confirming receptor-independent activity

Not required, but helpful