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Gerloff et al

Declining NAD+ levels are associated with aging, reduced cellular energy, and impaired metabolic function

Behavioral problems and mental stress Chronic stress increases cortisol levels and oxidative stress, resulting in accelerated GSH depletion

cvab182 (2021)

The reduction of gastric juice volume by NSAIDs, without reducing hydrogen ions, leads to the formation of inflammatory foci, which subsequently develops into gastric ulcer disease