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Curcumin can also compete with LPS for TLR4 receptor activation, thereby inhibiting the TLR4/myeloid differentiation 88 (MyD88)/NF-B signaling pathways (150, 151)

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a complex disorder characterized by extreme fatigue that lasts for at least six months and cannot be fully explained by an underlying medical condition

[213] Peak plasma concentrations are generally achieved within this timeframe, corresponding to the development of therapeutic effects

This study highlights OIs promising role in treating IBD