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The immunopeptidome of ECN90 -cells is dominated by insulin granule proteins and its breadth is increased by IFN- Building on this observation of increased peptide breadth induced by IFN-, we set forth to identify the features of this expanded immunopeptidome

For instance, as a consequence of tolerance restrictions, a lack of hypoxia specificity, or the selectivity on HIF isoforms, only a small number of them are now undergoing clinical trials