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Increased oxidative stress

A combination concept (tesofensine + metoprolol) has received orphan drug designation for Prader-Willi Syndrome, but this does not constitute approval

However, the presence of bound molecules (UTP, or UTP/ATP analog AMP-PCP/glutamine analog 5-oxo-L-norleucine) change the oligomeric state of PyrG from monomer to tetramer

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In any case, the effect of cuproptosis on PH and whether cuproptosis targets are activated or inhibited in pulmonary vascular cells are promising topics that need investigation