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Oxidants and Nonspecific Oxidative Damage to Lipids, Proteins, and DNA Recent developments have questioned the validity of the original concept of oxidative stress, particularly due to the realization that individual signaling and control events occur through discrete redox pathways rather than through mechanisms that are directly responsive to a change in the global thiol/disulfide balance (186)

Stetinov V, Smetanov L, Grossmann V, Anzenbacher P

Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence

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[] The duration of the interventions in these trials ranged from 8 to 24 weeks