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Matrix metalloproteinases (MMPs), a zinc-dependent protease family, is induced by several inflammatory cytokines, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and NO (Prihadi et al., 2018

Abstract Pain and depression are leading causes of disability and of profound social and economic burden

Differential cerebral PA concentrations resulting from distinct administration routes likely underlie these varied outcomes

An association with numerous risk factors including age, diabetes mellitus, dyslipidaemia, hypertension, CVD, obesity, MetS, hyperhomocysteinemia, lack of exercise, smoking and drug use has been reported [255,258-269]

However, the diagnosis and treatment of patients with long COVID to date has made it very clear that the majority of patients experience a multi-system syndrome characterized by fatigue with post-exertional malaise, cognitive deficits, depressed mood, stress-related head and joint pain, insomnia and vegetative dysfunction [99]