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Complementary human atlas data integrating snRNA-seq and single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) further resolved quiescent, early primed, late primed, and differentiating MuSC states, showing that aging skews the balance toward prematurely primed ( FOS + , JUN + ) MuSCs and providing evidence for progressive exhaustion of the stem cell pool

Metabolomics revealed an increasing abundance of the immunomodulatory metabolite itaconate within the injury site

Keep the applicator saturated at all times

reported that cord blood-derived multipotent stem cells (CB-SCs) inhibited CD8 + NKG2D + T cell proliferation through HVEM/BTLA and PD-L1/PD-1 signaling pathways [49]

aureus overgrowth without significantly affecting commensal species like S