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It is rapidly cleared by renal filtration and degraded by proteases before sustaining meaningful receptor engagement in preclinical in vivo systems

The stuff about nitric oxide and blood vessel function made sense to me from a biological standpoint

& Cantley, L.C

Unfortunately, this trial did not pass Phase I with five of the seven enrolled patients experiencing serious adverse effects, including supraventricular tachycardia, convulsion, and pulmonary embolism