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Disordered metabolism in mice lacking irisin

The histone methyltransferase inhibitor 5-deoxy-5-methylthioadenosine (MTA) reverses histone methylation and prevents chromatin remodeling, effectively abrogating the trained immunity phenotype induced by oxLDL

To test this hypothesis, we treated HCT116 cells with or without 5FU with a range of ETC inhibitors, spanning CICIV (Fig