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H 2 S and pyruvate production with fluorescent probe detection Kinetic H 2 S production was measured using AzMC (Sigma #802409), which is a fluorogenic probe selectively reduced in the presence of H 2 S producing 7-amino-4-methylcoumarin 29 and detectable with excitation wavelength Exc 350 nm and emission wavelength Emi 445 nm

All other co-authors contributed intellectually to the designing, editing, and proofreading of the manuscript

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Recent studies demonstrated that KD improved motor function and protected dopaminergic neurons in MPTP-induced mouse model of PD [68]

The association of circulating glutamine levels and depression is still controversial in clinical settings, as our previous meta-analysis reported decreased glutamine levels in MDD patients [22], while unaltered levels were reported in other meta-analyses [48, 49]