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FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22

In addition, NAD + production by the NNT enhance SIRT3-mediated deacetylation and loss of NAD + -dependent deacetylase SIRT3 increases the acetylation of IDH2 at K413 and decreases its enzymatic activity by reducing dimerization, thus regulates mitochondrial redox status and promotes cell tumorigenesis in luminal B breast cancer, 137 and B cell malignancies

The x-axis and y-axis plots the cell types across seven processed datasets in an unsupervised dendrogram

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Villaverde A, Estvez M (2013) Carbonylation of myofibrillar proteins through the maillard pathway: effect of reducing sugars and reaction temperature