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In addition, Vldlr / mice have been established as a mouse model of subretinal fibrosis and nAMD pathologies 15,16

Among the 40 patients evaluable for response, 18 patients met the 12-week PFS primary endpoint, with one patient achieving a PR, and 27 patients achieving SD as the best response (Scott et al., 2022)

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While current research focuses predominantly on hepatocytes, potential Kupffer cell modulation in NASH-related inflammation and fibrosis warrants further investigation (78)