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The most common types of mechanical problems are as follows: Loose Body: With age, injury, or degeneration of bone or cartilage can cause a piece to break off and float in the joint space

Stepping up to 3% or 5% is an option for thicker skin, stubborn areas, or patients who've plateaued, but higher concentrations carry more irritation risk

Insulin, for example, is a peptide, as are widely used GLP-1 medications for diabetes and obesity such as Ozempic and Wegovy