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Xenobiotica 29(11):11811189

10.1016/j.jep.2020.113039 10 Apigenin inhibits recurrent bladder cancer (2025)

The authors explain that the reported wound-healing activity of TB-500 in literature may be due to its metabolite Ac-LKKTE rather than the parent form.30 Additionally, there have been some positive preclinical research outcomes for the use of TB4 for hair growth,31 neuroprotection,32 tympanic membrane perforations,33 and decreasing mortality in sepsis, but more clinical research is needed before these potential benefits can be considered applicable to humans.5 Are TB4 and TB-500 safe

Sensible, sparing use when clinically indicated remains appropriate

PMID: 18200035