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The presence of metals and metalloids (e.g., arsenic, chromium, lead, and nickel) in e-cigarette aerosols causes many adverse effects in different organs of humans, such as CVD [54], pulmonary injury and renal damage [55]

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Of note, depression and mania scores showed small increment from baseline to post-treatment, possibly caused by nicotine withdrawal

Additionally, integrating host genotyping and dietary profiling with microbiome data will refine stratification strategies and facilitate the development of individualized microbial risk signatures linked to tobacco exposure

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