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Many studies have identified a proximal AP-1 element (263 to 269) to be critical in mediating the effect of oxidative stress-induced increase in human GCLC transcription (Morales et al., 1997

Such modifications could alter target conformation or activity

Hydroxychloroquine is a classical therapeutic agent for RA, and its therapeutic mechanism is related to the inhibition of dendritic cell (DC) activation by blocking TLR9 activation (169)