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Genus-level networks (Figure S6B) identified high-centrality nodes such as Paludicola and Staphylococcus, suggesting their roles as keystone taxa

Stimulation with 6-hydroxydopamine (6-OHDA) markedly downregulates nuclear factor erythroid 2related factor 2 (NRF2) expression in PC-12 cells, elevates Fe 2+ and reactive oxygen species (ROS) levels, suppresses glutathione peroxidase 4 (GPX4), promotes both ferroptosis and apoptosis, inhibits cell proliferation, and causes neuronal damage

It then combines with oxygen and becomes sulfur dioxide

J Exp Bot 70(18):48354848

In the study by iauskait and his team, highly metastatic human colon carcinoma cells were treated with sulforaphane, a bioactive compound found in cruciferous vegetables, in combination with the FOLFOX regimen (a combination of 5-FU, leucovorin, and oxaliplatin) to demonstrate an additive anticancer effect