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Korolczuk et al

In the presence of neurological symptoms, following daily treatment, injections up to weekly or biweekly are indicated for six months before initiating monthly IM injections

PHGDH impairment has broad metabolic consequences, affecting serine availability, the TCA cycle anaplerosis, redox balance, energy metabolism, nutrient sensing, and cell signaling (59)

doi: 10.1016/j.cell.2015.08.016 271 IshiiGOchiaiANeriS

Fecal microbiome transplantation alleviates manganese-induced neurotoxicity by altering the composition and function of the gut microbiota via the cGAS-STING/NLRP3 pathway