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On the other hand, the deletion of PKD1 specifically in adipocytes protects the development of od liver steatosis evoked by HFD feeding [79]

Thus, female C/EBP uORF mice gain less fat upon aging similar to mice under CR or upon prolonged rapamycin treatment (Fang et al., 2013) ( figure supplement 4C ), which probably contributes to an improved health state upon aging and to the extension in lifespan

Treatment effect appears to be clinically evident starting from one to three months after treatment completion, with a subsequent progressive decrease of the achieved EF benefit over time, although some effects could be still detected up to five years after treatment [490,492,498]