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For efficient degradation, proteins must pass into the hollow 20S proteasomal core (92)

Discovery, synthesis, and structure-based optimization of a series of N -( tert -butyl)-2-( N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

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