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The problem with nicotine is that it gets people addicted to smoking, but cigarettes not nicotine are the killer

Figure 3 Discussion Our findings show that constipation is not influenced by serum cotinine levels or self-reported smoking habits

doi: 10.1034/j.1601-0825.2001.70206.x 49

This retrospective cohort study included a large sample of 10 338 subjects, which is larger than those of other studies, and it consistently measured subjects from the year 2000 (IFLS3) through 2007 (IFLS4) to 2015 (IFLS5), which provides strong associations between dependent and independent variables