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So if a certain joint in the left hand is affected, then that same joint in the right hand is also probably affected

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Covalent functionalisation forms stable bonds via amidation, esterification, or silylation, ensuring durable conjugation for drugs, proteins, or imaging agents, whereas non-covalent approaches rely on stacking, electrostatic interactions, adsorption, or chelation, ensuring reversible binding, well-suited for stimuli-responsive delivery [33]