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Some antioxidants, for example, may theoretically interfere with the controlled oxidative environment that supports certain stages of follicular development

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Several molecules, such as monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1 (CCL7), can initiate macrophage recruitment and chemotaxis to increase the magnitude of immune responses

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50,51 This energy deficiency triggers the collapse of the mitochondrial membrane potential ( m ) and the release of proapoptotic factors, which activate the caspase cascade and induce apoptosis or senescence