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Results of an in vitro study showed that ferroptosis mediated inflammation in LPS (lipopolysaccharide)-treated BEAS-2B cells, and treatment with Panaxydol in the study attenuated LPS-induced inflammation and ferroptosis by up-regulating the Keap1-Nrf2/HO-1 pathway (Li et al., 2021)

However, this is very rare since glutathione is a naturally occurring substance in the body and usually happens due to high doses of glutathione

This induction significantly reduces iron death markers, including PTGS2 and ACSL4, in NPCs by up to 70%

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Thus, knock-out of metabolic genes (mainly the 35 genes predicted to be essential by the consensus models) was performed utilising the IN-HOUSE (Fig