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J Exp Med

1955 Oct 1;2(4943):819-23

Chronic conditions: Diseases such as fibromyalgia, rheumatoid arthritis, and chronic fatigue syndrome involve persistent pain and tiredness

Key Takeaways "Safety" depends on context: Laboratory handling safety, compound purity, and clinical safety profiles are three different questions Purity is the #1 variable: A 98% pure peptide and a 70% pure peptide are not the same product contamination is the primary risk factor Third-party testing is the standard: Vendor-provided COAs are a starting point

Common impurities to check include truncated peptide sequences (Gly-His or His-Lys fragments), residual coupling reagents and protecting groups, counterion residues, free (uncomplexed) GHK, and excess copper salts