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Downstream effects via the active metabolite Pro-Gly-Pro, BDNF and NGF mRNA upregulation, and enkephalinase inhibition persist for 12 to 24 hours, which is why dosing frequency is set by downstream windows rather than plasma kinetics

One of the reasons for myocardial hypertrophy may be related to the decrease in K+ repolarization associated with the M3 muscarinic ACh receptor, which leads to the harmful myocardial remodeling

10.1016/j.rechem.2023.100935 95 KanalE