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4b), decreased serum zonulin concentrations (Fig

10.1016/j.jplph.2016.06.011 282

[3] Sulfur itself is able to exist in several different oxidation states

Glutathionylated proteins occur mainly in intracellular space because GSH is located in the cytoplasm and Cys residues of proteins are in a reduced form and able to form mixed disulfides

This elevated level induces oxidative stress, and lipid peroxidation results in the generation of ROS, which affect hepatocytes and decrease the synthesis of antioxidant enzymes