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130,131 Most studies indicate that IDH2 is also significantly upregulated in ESCC, 132 ovarian cancer, 133 lung cancer and other types of cancer, 134 playing a pro-oncogenic role

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The signals were quantified using Metamorph Imaging Software (Molecular Devices, San Jose, CA, USA)

The web server Metaboanalyst 5.0 was used to conduct univariate and multivariate statistical analyses [28, 29]

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